Welcome to Single Molecule Biophysics Lab
Our group leverages the power of biophysical concepts and single molecule tools to understand the biology of nucleic acids at molecular level and use of nucleic acids out of its biological context such as nanomaterial.
DNA nanostructure a is promising nanomaterial and can be programmed virtually into any well defined nanostructure. It offers unparalleled opportunity for bio-sensing, bio-imaging and biomedical applications. However, challenge remains in optimization of DNA nanostructure in putting it frontlines for sensing, imaging, and drug delivery.
Non-canonical secondary DNA structures are reported to regulate important biological processes and may be responsible for diseases. This makes non-canonical DNA structures as promising drug-targets. Therefore, investigating these unusual DNA structures and interaction with their interacting partners are important.
We combine single molecule experimental and computational approaches to study these interesting systems and explore structure-function-dynamics of biological macromolecules. Our experimental approaches include Total Internal Reflection Fluorescence Microscopy (TIRFM), Fluorescence Correlation Spectroscopy (FCS), single molecule fluorescence resonance energy transfer (smFRET), molecular biology and biochemistry. On the other hand, computational approaches compliment the experimental findings providing a complete picture of molecular processes.
DNA nanostructure a is promising nanomaterial and can be programmed virtually into any well defined nanostructure. It offers unparalleled opportunity for bio-sensing, bio-imaging and biomedical applications. However, challenge remains in optimization of DNA nanostructure in putting it frontlines for sensing, imaging, and drug delivery.
Non-canonical secondary DNA structures are reported to regulate important biological processes and may be responsible for diseases. This makes non-canonical DNA structures as promising drug-targets. Therefore, investigating these unusual DNA structures and interaction with their interacting partners are important.
We combine single molecule experimental and computational approaches to study these interesting systems and explore structure-function-dynamics of biological macromolecules. Our experimental approaches include Total Internal Reflection Fluorescence Microscopy (TIRFM), Fluorescence Correlation Spectroscopy (FCS), single molecule fluorescence resonance energy transfer (smFRET), molecular biology and biochemistry. On the other hand, computational approaches compliment the experimental findings providing a complete picture of molecular processes.
Sneak Peek
And more to come...........
We are actively looking for PhD students to work on these and other interesting projects in the lab
Join us!!
Join us!!
