Research
DNA nanostructures
DNA has emerged as an excellent candidate for designing and building molecular machines because it is biocompatible, easily programmable, highly specific and its thermodynamic and kinetic properties are well established. Very appealing prospects of DNA nanostructure are biosensors and drug delivering nanomachines in therapeutics. However, the challenges remain in the field are multiplex detection of biomarkers and targeted cargo delivery at intended site thus reducing the chance of harming normal cells. Our lab aims to utilize DNA nanostructures and nanomachines in therapeutics and nanobiomedical applications. Drop us a line to know more!! |
Non-canonical DNA structures
In addition to the canonical duplex structure DNA is capable of forming non-canonical DNA structures such as a triplex, G-quadruplex and i-motif, 4-way and 3-way junctions depending on the environmental conditions. Non-canonical DNA structures are reported to regulate important biological processes and may be responsible for diseases. This makes non-canonical DNA structures as promising drug-targets. Our group in interested in finding the mechanistic details behind forming these structures and the role of important interacting partners using single molecule fluorescence techniques. These studies are certainly required to open up future possibilities for therapeutic developments targeting DNA secondary structures. Interested to know more?? Shoot us an email! |
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